The Rhine and Main, Amsterdam to Nuremberg

Capital of the Netherlands, the magical Venice of the North is famous for its dazzling Golden Age of power and wealth during the 16th and 17th centuries. Today, it is a bustling wonderland of things to see and do. No visit is complete without a cruise along the intricate network of more than 62 miles (100 km) of canals and time with the Dutch masters at the renowned Rijksmuseum. Other highlights include the Royal Palace, Anne Frank House, lavish 17th-century canal homes, Heineken Beer Experience, and the infamous red-light district!

The city of Utrecht is an underappreciated whose ancient city center features structures dating back to the High Middle Ages. It has been the religious center of the Netherlands since the 8th century, and was the most important city in the Netherlands until the Dutch Golden Age, when it was surpassed by Amsterdam. Today, Utrecht is a city of lovely parks and canals, lively cafes, and remarkable historical buildings and museums. And no visit here is complete, of course, without the 465-step climb up the cathedral tower for incredible views over the city.

Proud international hub of business and finance, Düsseldorf is ranked the sixth-most-livable city in the world, but it wasn't always this way. It started as the marshland home of Germanic tribes before small farming and fishing settlements began cropping up in the 7th century. Today's highlights include the harbor, Gothic St. Lambertus Church with its twisted tower, the palace tower, and Germany's oldest inland navigation museum. Meanwhile, the 200-year Altbier tradition makes a taste of the copper-colored brew feel like sipping a piece of history.

Deep in the heart of the Rhine Gorge is the romantic wine village of Rüdesheim, one of the river's most popular ports. Home to some of Germany's finest vineyards, Rüdesheim is particularly famous for its Riesling, as well as its signature coffee made with German brandy, whipped cream, and chocolate shavings. Highlight attractions include the cable car up to the Niederwald Monument, which commemorates the unification of Germany in 1871, and the atmospheric Drosselgasse, lined with gorgeous Old World architecture, boutiques, and countless cozy wine taverns.

Miltenberg boasts some of Germany’s finest half-timbered architecture. Enter through Schwertfeger Gate to a lively market square framed by pink sandstone façades. Overlooking the town is Mildenburg Castle, while Hotel zum Riesen, one of Germany’s oldest inns, recalls both historic witch trials and centuries of hospitality. The town is also known for its Bavarian wines, beers, hearty game, sausage, and breads.

Freudenberg, a small town on the Main River in Germany, combines historic character with a peaceful riverside setting. Its medieval old town, with well-preserved half-timbered houses, reflects centuries of tradition, while the river brings a quiet charm to everyday life

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Bavarian Würzburg has layers of history. Magnificent Marienberg Fortress, for example, stands on a Roman fort and a 3,000-year-old Bronze Age castle. The first church where Würzburg Cathedral now stands was built as early as 788. During WWII, nearly 90% of the city was destroyed in a British air raid, but efforts later transformed the rubble into accurate restorations. Highlights include the Würzburg Residenz, one of Europe's most magnificent palaces; Marienberg Fortress; the statue-lined Old Main Bridge; and the Käppele pilgrimage site on Marienberg hill.

One of Germany's true masterpieces, the UNESCO World Heritage Site of Bamberg dates back to the 9th century, extending over seven church-capped hills. A lovely medieval Old Town features a grand, four-towered cathedral, founded in 1004; fishermen's huts lining the canal in the Little Venice district; and the unusual Old Town Hall, built in the middle of the river by residents in 1386 when the bishop refused to grant land for its construction! Bamberg is also famous for its signature smoked beer, brewed locally for centuries and part of the town's cultural heritage!

Nuremberg combines Old World beauty with a complex past. Surrounded by 14th-century walls, its Old Town is filled with landmarks such as the fortified Königstor gate, Nuremberg Castle, and the 12th-century Church of St. Sebald. Yet the city is equally known for its 20th-century history: once a major center of Nazi power, it later became the stage for the Nuremberg Trials, where leading war criminals were brought to justice. Today, the Beautiful Fountain still draws attention at the city’s heart, its brass rings said to bring good fortune to those who spin them.